| Date | Opponent | Result |
|---|---|---|
| 2/15 | @22Lynchburg | W 16-9 |
| 2/22 | 2Salisbury | L 11-12 |
| 3/1 | @14Stevenson | W 15-6 |
| 3/8 | @Wash. & Lee | W 16-13 |
| 3/14 | 6Chris. Newport | L 4-13 |
| 3/15 | 18Hamilton | W 10-6 |
| 3/22 | 11Swarthmore | W 12-11 |
| 3/29 | @Muhlenberg | W 10-9 |
| 4/2 | @15York (PA) | L 11-20 |
| 4/5 | @Haverford | W 16-6 |
| 4/9 | 21Dickinson | W 13-12 |
| 4/12 | Ursinus | W 20-10 |
| 4/16 | @McDaniel | W 21-3 |
| 4/19 | Washington Col. | W 16-5 |
| 4/26 | @Franklin & Marshall | W 11-10 |
| 5/2 | Winner from #5 Franklin & Marshall (11-5) vs. #4 Muhlenberg (9-8) 2025 Centennial Men's Lacrosse Tournament† | |
| †non-divisional |
| Rank | Name | Rating |
|---|---|---|
| 1 | Charlie Johnson | 6.30 |
| 2 | Jack Dunleavy | 6.03 |
| 3 | Jackson Barroll | 5.90 |
| 4 | Ethan Kessler | 5.28 |
| 5 | Patrick Maroney | 4.28 |
| 6 | Jackson Alpaugh | 4.11 |
| 7 | Jackson Hearn | 3.90 |
| 8 | Raffael Katts | 2.96 |
| 9 | Nicholas Limberg | 2.95 |
| 10 | Will Hedley | 2.90 |
| 11 | Oliver Duryee | 2.87 |
| 12 | Kevin Gillespie | 2.84 |
| 13 | Stokes Myers | 2.82 |
| 14 | Matt Maciolek | 2.82 |
| 15 | Luke Barbera | 2.72 |
| 16 | Declan Mack | 2.71 |
| 17 | Jake McLoy | 2.65 |
| 18 | Cooper Savoy | 2.64 |
| 19 | Henry Grosso | 2.61 |
| 20 | Vincent Ferrara | 2.53 |